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1z1x
From Proteopedia
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==Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution== | ==Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution== | ||
| - | <StructureSection load='1z1x' size='340' side='right' caption='[[1z1x]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='1z1x' size='340' side='right'caption='[[1z1x]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1z1x]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1z1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z1X FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1x OCA], [https://pdbe.org/1z1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z1x RCSB], [https://www.ebi.ac.uk/pdbsum/1z1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z1x ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DID_ECHCA DID_ECHCA] Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1x_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1x_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z1x ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Echis carinatus]] | [[Category: Echis carinatus]] | ||
| - | [[Category: Bilgrami | + | [[Category: Large Structures]] |
| - | [[Category: Ethayathulla | + | [[Category: Bilgrami S]] |
| - | [[Category: Hassan | + | [[Category: Ethayathulla AS]] |
| - | [[Category: Singh | + | [[Category: Hassan MI]] |
| - | [[Category: Singh | + | [[Category: Singh B]] |
| - | [[Category: Yadav | + | [[Category: Singh TP]] |
| - | + | [[Category: Yadav S]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution
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