2cw0

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==Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution==
==Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution==
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<StructureSection load='2cw0' size='340' side='right' caption='[[2cw0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='2cw0' size='340' side='right'caption='[[2cw0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cw0]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CW0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cw0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus], [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27] and [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CW0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw0 OCA], [http://pdbe.org/2cw0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cw0 RCSB], [http://www.ebi.ac.uk/pdbsum/2cw0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw0 OCA], [https://pdbe.org/2cw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cw0 RCSB], [https://www.ebi.ac.uk/pdbsum/2cw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cw0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPOZ_THET8 RPOZ_THET8]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). [[http://www.uniprot.org/uniprot/RPOA_THET8 RPOA_THET8]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOC_THET8 RPOC_THET8]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOB_THET8 RPOB_THET8]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/Q5SKW1_THET8 Q5SKW1_THET8]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity).[RuleBase:RU000715] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (By similarity).[HAMAP-Rule:MF_00963]
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[https://www.uniprot.org/uniprot/RPOA_THET8 RPOA_THET8] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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*[[Sigma factor|Sigma factor]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Arnold, E]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Birktoft, J J]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Borukhov, S]]
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[[Category: Arnold E]]
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[[Category: Clark, A D]]
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[[Category: Birktoft JJ]]
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[[Category: Dharia, C]]
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[[Category: Borukhov S]]
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[[Category: Ebright, R H]]
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[[Category: Clark Jr AD]]
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[[Category: Hudson, B]]
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[[Category: Dharia C]]
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[[Category: Ismail, S]]
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[[Category: Ebright RH]]
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[[Category: Laptenko, O]]
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[[Category: Hudson B]]
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[[Category: Lee, J]]
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[[Category: Ismail S]]
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[[Category: Leroy, O]]
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[[Category: Laptenko O]]
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[[Category: Mukhopadhyay, J]]
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[[Category: Lee J]]
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[[Category: Napoli, A]]
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[[Category: Leroy O]]
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[[Category: Sarafianos, S G]]
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[[Category: Mukhopadhyay J]]
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[[Category: Sineva, E]]
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[[Category: Napoli A]]
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[[Category: Tuske, S]]
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[[Category: Sarafianos SG]]
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[[Category: Wang, X]]
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[[Category: Sineva E]]
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[[Category: Bent-bridge helix]]
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[[Category: Tuske S]]
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[[Category: Rna polymerase holoenzyme]]
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[[Category: Wang X]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

PDB ID 2cw0

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