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2dc3

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(New page: 200px<br /> <applet load="2dc3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dc3, resolution 1.68&Aring;" /> '''Crystal structure o...)
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[[Image:2dc3.gif|left|200px]]<br />
 
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<applet load="2dc3" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dc3, resolution 1.68&Aring;" />
 
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'''Crystal structure of human cytoglobin at 1.68 angstroms resolution'''<br />
 
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==Overview==
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==Crystal structure of human cytoglobin at 1.68 angstroms resolution==
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Cytoglobin (Cgb) is a recently discovered member of the vertebrate, haem-containing globin family. The structure of a new crystal form of, wild-type human Cgb (space group C2) was determined at a resolution of, 1.68 Angstrom. The results show the presence of an additional helix in the, N-terminal residues (4-20) prior to the A helix and an ordered loop, structure in the C-terminal region (168-188), while these extended, peptides were invisible owing to disorder in the previously reported, structures using a P3(2)21 crystal at a resolution of 2.4 Angstrom. A, detailed comparison of the two crystal structures shows differences in the, conformation of the residues (i.e. Arg84) in the haem environment owing to, a different dimeric arrangement.
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<StructureSection load='2dc3' size='340' side='right'caption='[[2dc3]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DC3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dc3 OCA], [https://pdbe.org/2dc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2dc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dc3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dc3 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYGB_HUMAN CYGB_HUMAN] May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/2dc3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dc3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytoglobin (Cgb) is a recently discovered member of the vertebrate haem-containing globin family. The structure of a new crystal form of wild-type human Cgb (space group C2) was determined at a resolution of 1.68 Angstrom. The results show the presence of an additional helix in the N-terminal residues (4-20) prior to the A helix and an ordered loop structure in the C-terminal region (168-188), while these extended peptides were invisible owing to disorder in the previously reported structures using a P3(2)21 crystal at a resolution of 2.4 Angstrom. A detailed comparison of the two crystal structures shows differences in the conformation of the residues (i.e. Arg84) in the haem environment owing to a different dimeric arrangement.
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==About this Structure==
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High-resolution structure of human cytoglobin: identification of extra N- and C-termini and a new dimerization mode.,Makino M, Sugimoto H, Sawai H, Kawada N, Yoshizato K, Shiro Y Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):671-7. Epub 2006, May 12. PMID:16699195<ref>PMID:16699195</ref>
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2DC3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HEM and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DC3 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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High-resolution structure of human cytoglobin: identification of extra N- and C-termini and a new dimerization mode., Makino M, Sugimoto H, Sawai H, Kawada N, Yoshizato K, Shiro Y, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):671-7. Epub 2006, May 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16699195 16699195]
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</div>
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<div class="pdbe-citations 2dc3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kawada, N.]]
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[[Category: Kawada N]]
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[[Category: Makino, M.]]
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[[Category: Makino M]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Sawai H]]
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[[Category: Sawai, H.]]
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[[Category: Shiro Y]]
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[[Category: Shiro, Y.]]
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[[Category: Sugimoto H]]
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[[Category: Sugimoto, H.]]
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[[Category: Yoshizato K]]
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[[Category: Yoshizato, K.]]
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[[Category: ACY]]
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[[Category: HEM]]
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[[Category: cytoglobin]]
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[[Category: heme]]
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[[Category: myoglobin]]
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[[Category: oxygen storage]]
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[[Category: oxygen transport]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:30:52 2007''
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Current revision

Crystal structure of human cytoglobin at 1.68 angstroms resolution

PDB ID 2dc3

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