2dfh

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[[Image:2dfh.gif|left|200px]]
 
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==Crystal structure of Tk-RNase HII(1-212)-C==
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The line below this paragraph, containing "STRUCTURE_2dfh", creates the "Structure Box" on the page.
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<StructureSection load='2dfh' size='340' side='right'caption='[[2dfh]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DFH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dfh OCA], [https://pdbe.org/2dfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dfh RCSB], [https://www.ebi.ac.uk/pdbsum/2dfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dfh ProSAT]</span></td></tr>
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{{STRUCTURE_2dfh| PDB=2dfh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNH2_THEKO RNH2_THEKO] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/2dfh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dfh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
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'''Crystal structure of Tk-RNase HII(1-212)-C'''
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Conformational contagion in a protein: structural properties of a chameleon sequence.,Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955<ref>PMID:17510955</ref>
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==Overview==
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Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2DFH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermococcus_kodakarensis Thermococcus kodakarensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFH OCA].
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</div>
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<div class="pdbe-citations 2dfh" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Conformational contagion in a protein: structural properties of a chameleon sequence., Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S, Proteins. 2007 Aug 15;68(3):617-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17510955 17510955]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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[[Category: Ribonuclease H]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Thermococcus kodakarensis]]
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__TOC__
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[[Category: Chon, H.]]
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</StructureSection>
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[[Category: Kanaya, S.]]
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[[Category: Large Structures]]
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[[Category: Katagiri, Y.]]
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[[Category: Thermococcus kodakarensis KOD1]]
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[[Category: Koga, Y.]]
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[[Category: Chon H]]
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[[Category: Matsumura, H.]]
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[[Category: Kanaya S]]
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[[Category: Takano, K.]]
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[[Category: Katagiri Y]]
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[[Category: Chameleon sequence]]
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[[Category: Koga Y]]
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[[Category: Fusion protein]]
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[[Category: Matsumura H]]
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[[Category: Ribonuclease hii]]
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[[Category: Takano K]]
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[[Category: Thermococcus kodakaraensis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:19:11 2008''
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Current revision

Crystal structure of Tk-RNase HII(1-212)-C

PDB ID 2dfh

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