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2e43

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[[Image:2e43.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment==
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|PDB= 2e43 |SIZE=350|CAPTION= <scene name='initialview01'>2e43</scene>, resolution 2.10&Aring;
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<StructureSection load='2e43' size='340' side='right'caption='[[2e43]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2e43]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E43 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= CEBPB, TCF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e43 OCA], [https://pdbe.org/2e43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e43 RCSB], [https://www.ebi.ac.uk/pdbsum/2e43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e43 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e43 TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment'''
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[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2E43 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/2e43_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e43 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hamada, K.]]
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[[Category: Hamada K]]
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[[Category: Inoue-Bungo, T.]]
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[[Category: Inoue-Bungo T]]
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[[Category: Ogata, K.]]
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[[Category: Ogata K]]
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[[Category: Sato, K.]]
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[[Category: Sato K]]
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[[Category: Shiina, M.]]
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[[Category: Shiina M]]
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[[Category: Tahirov, T H.]]
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[[Category: Tahirov TH]]
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[[Category: protein-dna complex]]
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[[Category: transcription/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:35:05 2008''
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Current revision

Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment

PDB ID 2e43

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