This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2e68

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2e68" [edit=sysop:move=sysop])
Current revision (08:35, 25 October 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2e68.png|left|200px]]
 
-
<!--
+
==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate==
-
The line below this paragraph, containing "STRUCTURE_2e68", creates the "Structure Box" on the page.
+
<StructureSection load='2e68' size='340' side='right'caption='[[2e68]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E68 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-
{{STRUCTURE_2e68| PDB=2e68 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e68 OCA], [https://pdbe.org/2e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e68 RCSB], [https://www.ebi.ac.uk/pdbsum/2e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e68 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e68_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e68 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate===
+
==See Also==
-
 
+
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_018808149}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 018808149 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_018808149}}
+
-
 
+
-
==About this Structure==
+
-
[[2e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:018808149</ref><references group="xtra"/>
+
-
[[Category: Dihydroorotate oxidase]]
+
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
-
[[Category: Aoki, T.]]
+
[[Category: Aoki T]]
-
[[Category: Harada, S.]]
+
[[Category: Harada S]]
-
[[Category: Inaoka, D K.]]
+
[[Category: Inaoka DK]]
-
[[Category: Kita, K.]]
+
[[Category: Kita K]]
-
[[Category: Kurisu, G.]]
+
[[Category: Kurisu G]]
-
[[Category: Nara, T.]]
+
[[Category: Nara T]]
-
[[Category: Sakamoto, K.]]
+
[[Category: Sakamoto K]]
-
[[Category: Shiba, T.]]
+
[[Category: Shiba T]]
-
[[Category: Shimizu, H.]]
+
[[Category: Shimizu H]]
-
[[Category: Chagas disease]]
+
-
[[Category: Dihydroorotate dehydrogenase]]
+
-
[[Category: Energy metabolism]]
+
-
[[Category: Flavoprotein]]
+
-
[[Category: Fumarate reductase]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Pyrimidine biosynthesis]]
+
-
[[Category: Redox homeostasis]]
+

Current revision

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate

PDB ID 2e68

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e68"
Personal tools