This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2eit

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:41, 25 October 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2eit.jpg|left|200px]]<br /><applet load="2eit" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2eit, resolution 1.65&Aring;" />
 
-
'''Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-alanine and NAD'''<br />
 
-
==About this Structure==
+
==Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-alanine and NAD==
-
2EIT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=ALA:'>ALA</scene>, <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/1-pyrroline-5-carboxylate_dehydrogenase 1-pyrroline-5-carboxylate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.12 1.5.1.12] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EIT OCA].
+
<StructureSection load='2eit' size='340' side='right'caption='[[2eit]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-
[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2eit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EIT FirstGlance]. <br>
-
[[Category: Thermus thermophilus]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
[[Category: Inagaki, E.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eit OCA], [https://pdbe.org/2eit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eit RCSB], [https://www.ebi.ac.uk/pdbsum/2eit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eit ProSAT], [https://www.topsan.org/Proteins/RSGI/2eit TOPSAN]</span></td></tr>
-
[[Category: Sakamoto, K.]]
+
</table>
-
[[Category: Yokoyama, S.]]
+
== Function ==
-
[[Category: ACT]]
+
[https://www.uniprot.org/uniprot/Q5SI02_THET8 Q5SI02_THET8]
-
[[Category: ALA]]
+
== Evolutionary Conservation ==
-
[[Category: MPD]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: NA]]
+
Check<jmol>
-
[[Category: NAD]]
+
<jmolCheckbox>
-
[[Category: enzyme-coenzyme-inhibitor ternary complex]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/2eit_consurf.spt"</scriptWhenChecked>
-
[[Category: national project on protein structural and functional analyses]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: nppsfa]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: oxidoreductase]]
+
</jmolCheckbox>
-
[[Category: riken structural genomics/proteomics initiative]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eit ConSurf].
-
[[Category: rsgi]]
+
<div style="clear:both"></div>
-
[[Category: structural genomics]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:10:58 2008''
+
==See Also==
 +
*[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Thermus thermophilus HB8]]
 +
[[Category: Inagaki E]]
 +
[[Category: Sakamoto K]]
 +
[[Category: Yokoyama S]]

Current revision

Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-alanine and NAD

PDB ID 2eit

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eit"
Personal tools