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2ej3

From Proteopedia

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[[Image:2ej3.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with Gabapentin==
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|PDB= 2ej3 |SIZE=350|CAPTION= <scene name='initialview01'>2ej3</scene>, resolution 2.20&Aring;
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<StructureSection load='2ej3' size='340' side='right'caption='[[2ej3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Plp+Binding+Site+For+Residue+A+413'>AC1</scene>, <scene name='pdbsite=AC2:Plp+Binding+Site+For+Residue+B+913'>AC2</scene>, <scene name='pdbsite=AC3:Plp+Binding+Site+For+Residue+C+1413'>AC3</scene>, <scene name='pdbsite=AC4:Gbn+Binding+Site+For+Residue+A+2414'>AC4</scene>, <scene name='pdbsite=AC5:Gbn+Binding+Site+For+Residue+B+914'>AC5</scene>, <scene name='pdbsite=AC6:Gbn+Binding+Site+For+Residue+C+1414'>AC6</scene>, <scene name='pdbsite=AC7:Mpd+Binding+Site+For+Residue+A+2416'>AC7</scene>, <scene name='pdbsite=AC8:Mpd+Binding+Site+For+Residue+A+1417'>AC8</scene>, <scene name='pdbsite=AC9:Mpd+Binding+Site+For+Residue+B+915'>AC9</scene>, <scene name='pdbsite=BC1:Mpd+Binding+Site+For+Residue+B+917'>BC1</scene> and <scene name='pdbsite=BC2:Mpd+Binding+Site+For+Residue+C+1416'>BC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GBN:[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC+ACID'>GBN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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<table><tr><td colspan='2'>[[2ej3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EJ3 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Branched-chain-amino-acid_transaminase Branched-chain-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.42 2.6.1.42] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBN:[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC+ACID'>GBN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ej3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ej3 OCA], [https://pdbe.org/2ej3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ej3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ej3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ej3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ej3 TOPSAN]</span></td></tr>
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|RELATEDENTRY=[[2eiy|2EIY]], [[2ej0|2EJ0]], [[2ej2|2EJ2]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ej3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ej3 OCA], [http://www.ebi.ac.uk/pdbsum/2ej3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ej3 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q5SM19_THET8 Q5SM19_THET8]
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== Evolutionary Conservation ==
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'''Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with Gabapentin'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/2ej3_consurf.spt"</scriptWhenChecked>
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2EJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJ3 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Branched-chain-amino-acid transaminase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Thermus thermophilus]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ej3 ConSurf].
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[[Category: Goto, M.]]
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<div style="clear:both"></div>
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[[Category: plp-dependent enzyme]]
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__TOC__
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[[Category: transferase]]
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</StructureSection>
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[[Category: Large Structures]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:49:53 2008''
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[[Category: Thermus thermophilus HB8]]
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[[Category: Goto M]]

Current revision

Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with Gabapentin

PDB ID 2ej3

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