2f11

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:44, 25 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2f11' size='340' side='right'caption='[[2f11]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
<StructureSection load='2f11' size='340' side='right'caption='[[2f11]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F11 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F11 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEM:5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC+ACID'>IEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sn7|1sn7]], [[1so7|1so7]], [[1vcu|1vcu]], [[2f0z|2f0z]], [[2f10|2f10]], [[2f12|2f12]], [[2f13|2f13]], [[2f24|2f24]], [[2f25|2f25]], [[2f26|2f26]], [[2f27|2f27]], [[2f28|2f28]], [[2f29|2f29]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEM:5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC+ACID'>IEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f11 OCA], [https://pdbe.org/2f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f11 RCSB], [https://www.ebi.ac.uk/pdbsum/2f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f11 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f11 OCA], [https://pdbe.org/2f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f11 RCSB], [https://www.ebi.ac.uk/pdbsum/2f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.
+
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 26: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chavas, L M.G]]
+
[[Category: Chavas LMG]]
-
[[Category: Dyason, J C]]
+
[[Category: Dyason JC]]
-
[[Category: Fusi, P]]
+
[[Category: Fusi P]]
-
[[Category: Itzstein, M von]]
+
[[Category: Kato R]]
-
[[Category: Kato, R]]
+
[[Category: Mann MC]]
-
[[Category: Mann, M C]]
+
[[Category: Monti E]]
-
[[Category: Monti, E]]
+
[[Category: Tettamanti G]]
-
[[Category: Tettamanti, G]]
+
[[Category: Thomson RJ]]
-
[[Category: Thomson, R J]]
+
[[Category: Tringali C]]
-
[[Category: Tringali, C]]
+
[[Category: Venerando B]]
-
[[Category: Venerando, B]]
+
[[Category: Wakatsuki S]]
-
[[Category: Wakatsuki, S]]
+
[[Category: Von Itzstein M]]
-
[[Category: Drug design]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Influenza virus]]
+
-
[[Category: Neuraminidase]]
+
-
[[Category: Sialidase]]
+

Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

PDB ID 2f11

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools