2f11

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2f11" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f11, resolution 2.57&Aring;" /> '''Crystal Structure o...)
Current revision (08:44, 25 October 2023) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f11.gif|left|200px]]<br />
 
-
<applet load="2f11" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2f11, resolution 2.57&Aring;" />
 
-
'''Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor'''<br />
 
-
==About this Structure==
+
==Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor==
-
2F11 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4 and IEM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA].
+
<StructureSection load='2f11' size='340' side='right'caption='[[2f11]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-
[[Category: Exo-alpha-sialidase]]
+
== Structural highlights ==
-
[[Category: Homo sapiens]]
+
<table><tr><td colspan='2'>[[2f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F11 FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
-
[[Category: Chavas, L.M.G.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEM:5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC+ACID'>IEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
[[Category: Dyason, J.C.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f11 OCA], [https://pdbe.org/2f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f11 RCSB], [https://www.ebi.ac.uk/pdbsum/2f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f11 ProSAT]</span></td></tr>
-
[[Category: Fusi, P.]]
+
</table>
-
[[Category: Itzstein, M.von.]]
+
== Function ==
-
[[Category: Kato, R.]]
+
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
-
[[Category: Mann, M.C.]]
+
== Evolutionary Conservation ==
-
[[Category: Monti, E.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Tettamanti, G.]]
+
Check<jmol>
-
[[Category: Thomson, R.J.]]
+
<jmolCheckbox>
-
[[Category: Tringali, C.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f11_consurf.spt"</scriptWhenChecked>
-
[[Category: Venerando, B.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Wakatsuki, S.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: IEM]]
+
</jmolCheckbox>
-
[[Category: PO4]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f11 ConSurf].
-
[[Category: drug design]]
+
<div style="clear:both"></div>
-
[[Category: influenza virus]]
+
-
[[Category: neuraminidase]]
+
-
[[Category: sialidase]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:58:07 2007''
+
==See Also==
 +
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Chavas LMG]]
 +
[[Category: Dyason JC]]
 +
[[Category: Fusi P]]
 +
[[Category: Kato R]]
 +
[[Category: Mann MC]]
 +
[[Category: Monti E]]
 +
[[Category: Tettamanti G]]
 +
[[Category: Thomson RJ]]
 +
[[Category: Tringali C]]
 +
[[Category: Venerando B]]
 +
[[Category: Wakatsuki S]]
 +
[[Category: Von Itzstein M]]

Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

PDB ID 2f11

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f11"
Personal tools