2f11

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:44, 25 October 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f11.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor==
-
The line below this paragraph, containing "STRUCTURE_2f11", creates the "Structure Box" on the page.
+
<StructureSection load='2f11' size='340' side='right'caption='[[2f11]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F11 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEM:5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC+ACID'>IEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_2f11| PDB=2f11 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f11 OCA], [https://pdbe.org/2f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f11 RCSB], [https://www.ebi.ac.uk/pdbsum/2f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f11 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f11_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f11 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor'''
+
==See Also==
-
 
+
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2F11 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F11 OCA].
+
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Chavas, L M.G.]]
+
[[Category: Chavas LMG]]
-
[[Category: Dyason, J C.]]
+
[[Category: Dyason JC]]
-
[[Category: Fusi, P.]]
+
[[Category: Fusi P]]
-
[[Category: Itzstein, M von.]]
+
[[Category: Kato R]]
-
[[Category: Kato, R.]]
+
[[Category: Mann MC]]
-
[[Category: Mann, M C.]]
+
[[Category: Monti E]]
-
[[Category: Monti, E.]]
+
[[Category: Tettamanti G]]
-
[[Category: Tettamanti, G.]]
+
[[Category: Thomson RJ]]
-
[[Category: Thomson, R J.]]
+
[[Category: Tringali C]]
-
[[Category: Tringali, C.]]
+
[[Category: Venerando B]]
-
[[Category: Venerando, B.]]
+
[[Category: Wakatsuki S]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Von Itzstein M]]
-
[[Category: Drug design]]
+
-
[[Category: Influenza virus]]
+
-
[[Category: Neuraminidase]]
+
-
[[Category: Sialidase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:00 2008''
+

Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

PDB ID 2f11

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f11"
Personal tools