This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ggq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2ggq" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ggq, resolution 2.00&Aring;" /> '''complex of hypotheti...)
Current revision (08:49, 25 October 2023) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ggq.gif|left|200px]]<br /><applet load="2ggq" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2ggq, resolution 2.00&Aring;" />
 
-
'''complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii'''<br />
 
-
==About this Structure==
+
==complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii==
-
2GGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii] with <scene name='pdbligand=IOD:'>IOD</scene> and <scene name='pdbligand=TTP:'>TTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGQ OCA].
+
<StructureSection load='2ggq' size='340' side='right'caption='[[2ggq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
[[Category: Glucose-1-phosphate thymidylyltransferase]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGQ FirstGlance]. <br>
-
[[Category: Sulfolobus tokodaii]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
[[Category: Kuramitsu, S.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
-
[[Category: Masui, R.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggq OCA], [https://pdbe.org/2ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggq RCSB], [https://www.ebi.ac.uk/pdbsum/2ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggq ProSAT]</span></td></tr>
-
[[Category: Mizushima, T.]]
+
</table>
-
[[Category: Rajakannan, V.]]
+
== Function ==
-
[[Category: Suzuki, A.]]
+
[https://www.uniprot.org/uniprot/S1PNA_SULTO S1PNA_SULTO] Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).<ref>PMID:15598657</ref> <ref>PMID:20400541</ref> <ref>PMID:25567746</ref> <ref>PMID:27864169</ref> <ref>PMID:30291121</ref>
-
[[Category: Yamane, T.]]
+
== Evolutionary Conservation ==
-
[[Category: IOD]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: TTP]]
+
Check<jmol>
-
[[Category: beta barrel]]
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggq_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggq ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:58:59 2008''
+
==See Also==
 +
*[[Glucose-1-phosphate thymidylyltransferase 3D structures|Glucose-1-phosphate thymidylyltransferase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Sulfurisphaera tokodaii]]
 +
[[Category: Kuramitsu S]]
 +
[[Category: Masui R]]
 +
[[Category: Mizushima T]]
 +
[[Category: Rajakannan V]]
 +
[[Category: Suzuki A]]
 +
[[Category: Yamane T]]

Current revision

complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii

PDB ID 2ggq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ggq"
Personal tools