This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2hrb
From Proteopedia
(Difference between revisions)
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2hrb.gif|left|200px]]<br /><applet load="2hrb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2hrb, resolution 1.90Å" /> | ||
| - | '''Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+'''<br /> | ||
| - | == | + | ==Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+== |
| - | + | <StructureSection load='2hrb' size='340' side='right'caption='[[2hrb]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2hrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HRB FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hrb OCA], [https://pdbe.org/2hrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hrb RCSB], [https://www.ebi.ac.uk/pdbsum/2hrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hrb ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [https://www.uniprot.org/uniprot/CBR3_HUMAN CBR3_HUMAN] Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).<ref>PMID:18493841</ref> |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hrb_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hrb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Carbonyl reductase 3D structures|Carbonyl reductase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pilka ES]] | ||
Current revision
Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+
| |||||||||||
