2hu2

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==CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide==
==CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide==
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<StructureSection load='2hu2' size='340' side='right' caption='[[2hu2]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='2hu2' size='340' side='right'caption='[[2hu2]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HU2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HU2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hku|1hku]], [[1hl3|1hl3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ctbp1, Bars, Ctbp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu2 OCA], [https://pdbe.org/2hu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu2 OCA], [http://pdbe.org/2hu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hu2 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CTBP1_RAT CTBP1_RAT]] Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Functions in brown adipose tissue (BAT) differentiation.<ref>PMID:10364211</ref> <ref>PMID:7624370</ref> <ref>PMID:12805226</ref> [[http://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN]] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>
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[https://www.uniprot.org/uniprot/Q6AZ26_RAT Q6AZ26_RAT]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hu2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hu2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hu2 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Homo sapiens]]
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[[Category: Bolognesi, M]]
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[[Category: Large Structures]]
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[[Category: Crossley, M]]
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[[Category: Rattus norvegicus]]
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[[Category: Francescato, P]]
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[[Category: Bolognesi M]]
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[[Category: Nardini, M]]
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[[Category: Crossley M]]
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[[Category: Quinlan, K G.R]]
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[[Category: Francescato P]]
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[[Category: Verger, A]]
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[[Category: Nardini M]]
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[[Category: Oxidoreductase]]
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[[Category: Quinlan KGR]]
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[[Category: Transcription co-repressor]]
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[[Category: Verger A]]
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[[Category: Zinc finger protein]]
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Current revision

CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide

PDB ID 2hu2

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