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2p1b
From Proteopedia
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| - | [[Image:2p1b.jpg|left|200px]]<br /><applet load="2p1b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2p1b, resolution 2.75Å" /> | ||
| - | '''Crystal structure of human nucleophosmin-core'''<br /> | ||
| - | == | + | ==Crystal structure of human nucleophosmin-core== |
| - | + | <StructureSection load='2p1b' size='340' side='right'caption='[[2p1b]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2p1b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1B FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1b OCA], [https://pdbe.org/2p1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1b RCSB], [https://www.ebi.ac.uk/pdbsum/2p1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1b ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | + | == Disease == | |
| + | [https://www.uniprot.org/uniprot/NPM_HUMAN NPM_HUMAN] Note=A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. Note=A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA. Note=A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1. Note=Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NPM_HUMAN NPM_HUMAN] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.<ref>PMID:16107701</ref> <ref>PMID:17015463</ref> <ref>PMID:18809582</ref> <ref>PMID:19188445</ref> <ref>PMID:20352051</ref> <ref>PMID:21084279</ref> <ref>PMID:22002061</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ha | + | [[Category: Ha JY]] |
| - | [[Category: Jung | + | [[Category: Jung G]] |
| - | [[Category: Kang | + | [[Category: Kang JY]] |
| - | [[Category: Kim | + | [[Category: Kim HS]] |
| - | [[Category: Lee | + | [[Category: Lee BI]] |
| - | [[Category: Lee | + | [[Category: Lee HH]] |
| - | [[Category: Lim | + | [[Category: Lim SO]] |
| - | [[Category: Suh | + | [[Category: Suh SW]] |
| - | [[Category: Yoon | + | [[Category: Yoon HJ]] |
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Current revision
Crystal structure of human nucleophosmin-core
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Categories: Homo sapiens | Large Structures | Ha JY | Jung G | Kang JY | Kim HS | Lee BI | Lee HH | Lim SO | Suh SW | Yoon HJ
