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2r9y

From Proteopedia

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Current revision (09:03, 25 October 2023) (edit) (undo)
 
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==Structure of antiplasmin==
==Structure of antiplasmin==
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<StructureSection load='2r9y' size='340' side='right' caption='[[2r9y]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='2r9y' size='340' side='right'caption='[[2r9y]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9Y FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Serpinf2, Pli ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9y OCA], [http://pdbe.org/2r9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9y RCSB], [http://www.ebi.ac.uk/pdbsum/2r9y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9y OCA], [https://pdbe.org/2r9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9y RCSB], [https://www.ebi.ac.uk/pdbsum/2r9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A2AP_MOUSE A2AP_MOUSE]] Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).
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[https://www.uniprot.org/uniprot/A2AP_MOUSE A2AP_MOUSE] Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9y_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Buckle, A M]]
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[[Category: Mus musculus]]
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[[Category: Coughlin, P B]]
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[[Category: Buckle AM]]
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[[Category: Hitchen, C R]]
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[[Category: Coughlin PB]]
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[[Category: Horvath, A J]]
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[[Category: Hitchen CR]]
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[[Category: Kan, W T]]
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[[Category: Horvath AJ]]
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[[Category: Langendorf, C G]]
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[[Category: Kan WT]]
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[[Category: Law, R H.P]]
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[[Category: Langendorf CG]]
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[[Category: Sofian, T]]
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[[Category: Law RHP]]
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[[Category: Whisstock, J C]]
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[[Category: Sofian T]]
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[[Category: Acute phase]]
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[[Category: Whisstock JC]]
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[[Category: Alpha2-antiplasmin]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Inhibitory serpin]]
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[[Category: Plasmin inhibitor]]
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[[Category: Protease inhibitor]]
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[[Category: Secreted]]
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[[Category: Serine protease inhibitor]]
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[[Category: Sulfation]]
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[[Category: Toxin]]
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Current revision

Structure of antiplasmin

PDB ID 2r9y

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