This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2rd4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:03, 25 October 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2rd4.png|left|200px]]
 
-
<!--
+
==Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution==
-
The line below this paragraph, containing "STRUCTURE_2rd4", creates the "Structure Box" on the page.
+
<StructureSection load='2rd4' size='340' side='right'caption='[[2rd4]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2rd4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_2rd4| PDB=2rd4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd4 OCA], [https://pdbe.org/2rd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PA2B1_NAJSG PA2B1_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd4 ConSurf].
 +
<div style="clear:both"></div>
-
===Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution===
+
==See Also==
-
 
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2RD4 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA].
+
[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
-
[[Category: Kaur, A.]]
+
[[Category: Kaur A]]
-
[[Category: Kaur, P.]]
+
[[Category: Kaur P]]
-
[[Category: Mirza, Z.]]
+
[[Category: Mirza Z]]
-
[[Category: Sharma, S.]]
+
[[Category: Sharma S]]
-
[[Category: Singh, N.]]
+
[[Category: Singh N]]
-
[[Category: Singh, T P.]]
+
[[Category: Singh TP]]
-
[[Category: Sinha, M.]]
+
[[Category: Sinha M]]
-
[[Category: Srinivasan, A.]]
+
[[Category: Srinivasan A]]
-
[[Category: Calcium]]
+
-
[[Category: Complex]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Lipid degradation]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Peptide inhibitor]]
+
-
[[Category: Phospholipase a2]]
+
-
[[Category: Secreted]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:58:27 2009''
+

Current revision

Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution

PDB ID 2rd4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rd4"
Personal tools