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2ywk
From Proteopedia
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==Crystal structure of RRM-domain derived from human putative RNA-binding protein 11== | ==Crystal structure of RRM-domain derived from human putative RNA-binding protein 11== | ||
| - | <StructureSection load='2ywk' size='340' side='right' caption='[[2ywk]], [[Resolution|resolution]] 1.54Å' scene=''> | + | <StructureSection load='2ywk' size='340' side='right'caption='[[2ywk]], [[Resolution|resolution]] 1.54Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ywk]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ywk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YWK FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ywk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ywk OCA], [https://pdbe.org/2ywk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ywk RCSB], [https://www.ebi.ac.uk/pdbsum/2ywk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ywk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ywk TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBM11_HUMAN RBM11_HUMAN] Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.<ref>PMID:21984414</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywk_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywk_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ywk ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kaminishi | + | [[Category: Large Structures]] |
| - | [[Category: Kawazoe | + | [[Category: Kaminishi T]] |
| - | [[Category: Morita | + | [[Category: Kawazoe M]] |
| - | [[Category: Nishino | + | [[Category: Morita S]] |
| - | + | [[Category: Nishino A]] | |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Takemoto | + | [[Category: Takemoto C]] |
| - | [[Category: Terada | + | [[Category: Terada T]] |
| - | [[Category: Uchikubo-Kamo | + | [[Category: Uchikubo-Kamo T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Crystal structure of RRM-domain derived from human putative RNA-binding protein 11
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Categories: Homo sapiens | Large Structures | Kaminishi T | Kawazoe M | Morita S | Nishino A | Shirouzu M | Takemoto C | Terada T | Uchikubo-Kamo T | Yokoyama S
