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2yxr

From Proteopedia

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[[Image:2yxr.jpg|left|200px]]
 
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==The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal==
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The line below this paragraph, containing "STRUCTURE_2yxr", creates the "Structure Box" on the page.
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<StructureSection load='2yxr' size='340' side='right'caption='[[2yxr]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yxr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxr OCA], [https://pdbe.org/2yxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxr RCSB], [https://www.ebi.ac.uk/pdbsum/2yxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxr ProSAT]</span></td></tr>
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{{STRUCTURE_2yxr| PDB=2yxr | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECY_METJA SECY_METJA] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxr ConSurf].
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<div style="clear:both"></div>
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'''The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal'''
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==See Also==
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*[[Preprotein translocase|Preprotein translocase]]
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
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==About this Structure==
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__TOC__
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2YXR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXR OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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Puzzle plugged by protein pore plasticity., Minor DL Jr, Mol Cell. 2007 May 25;26(4):459-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17531803 17531803]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Protein complex]]
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[[Category: Li W]]
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[[Category: Li, W.]]
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[[Category: Schulman S]]
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[[Category: Schulman, S.]]
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[[Category: Membrane protein]]
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[[Category: Prl mutation]]
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[[Category: Protein secretion]]
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[[Category: Protein translocation]]
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[[Category: Protein transport]]
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[[Category: Signal peptide]]
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[[Category: Translocon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:39:50 2008''
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Current revision

The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal

PDB ID 2yxr

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