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6bvt

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==Importin alpha 1 in cargo free state==
==Importin alpha 1 in cargo free state==
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<StructureSection load='6bvt' size='340' side='right' caption='[[6bvt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='6bvt' size='340' side='right'caption='[[6bvt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bvt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BVT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BVT FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bvt OCA], [http://pdbe.org/6bvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bvt RCSB], [http://www.ebi.ac.uk/pdbsum/6bvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bvt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bvt OCA], [https://pdbe.org/6bvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bvt RCSB], [https://www.ebi.ac.uk/pdbsum/6bvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Importin|Importin]]
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*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Aragao, D]]
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[[Category: Mus musculus]]
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[[Category: Basler, C F]]
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[[Category: Aragao D]]
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[[Category: Cross, E M]]
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[[Category: Basler CF]]
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[[Category: Edwards, M R]]
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[[Category: Cross EM]]
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[[Category: Forwood, J K]]
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[[Category: Edwards MR]]
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[[Category: Smith, K M]]
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[[Category: Forwood JK]]
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[[Category: Tsimablyuk, S]]
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[[Category: Smith KM]]
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[[Category: Importin]]
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[[Category: Tsimablyuk S]]
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[[Category: Karyopherin]]
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[[Category: Nuclear]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

Importin alpha 1 in cargo free state

PDB ID 6bvt

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