7t91
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7t91 is ON HOLD Authors: Wu, M., Zhang, S., Augelli-Szanfran, C.E., Boohaker, R.J. Description: Crystal structure of Zinc finger motif 1 and 2 of G...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region== | |
| - | + | <StructureSection load='7t91' size='340' side='right'caption='[[7t91]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t91]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T91 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t91 OCA], [https://pdbe.org/7t91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t91 RCSB], [https://www.ebi.ac.uk/pdbsum/7t91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t91 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Wu | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Augelli-Szanfran CE]] | ||
| + | [[Category: Boohaker RJ]] | ||
| + | [[Category: Wu M]] | ||
| + | [[Category: Zhang S]] | ||
Current revision
Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region
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