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8d0a

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'''Unreleased structure'''
 
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The entry 8d0a is ON HOLD
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==Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab==
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<StructureSection load='8d0a' size='340' side='right'caption='[[8d0a]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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Authors: Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8d0a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D0A FirstGlance]. <br>
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Description: Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PKH:~{N}-[(1~{R},2~{R},4~{S},7~{E})-7-[azanyl(sulfanyl)methylidene]-7$l^{4}-azabicyclo[2.2.1]heptan-2-yl]-2-chloranyl-4-(6-cyclopropylpyrazin-2-yl)benzamide'>PKH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Butler, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d0a OCA], [https://pdbe.org/8d0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d0a RCSB], [https://www.ebi.ac.uk/pdbsum/8d0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d0a ProSAT]</span></td></tr>
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[[Category: Li, C]]
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</table>
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[[Category: Zhang, D]]
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== Function ==
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[[Category: Hao, Y]]
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[https://www.uniprot.org/uniprot/UBP30_HUMAN UBP30_HUMAN] Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).[UniProtKB:Q3UN04]<ref>PMID:18287522</ref> <ref>PMID:24896179</ref> <ref>PMID:25527291</ref> <ref>PMID:25621951</ref>
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[[Category: Song, X]]
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== References ==
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[[Category: Zhang, K]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Butler J]]
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[[Category: Hao Y]]
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[[Category: Li C]]
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[[Category: Song X]]
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[[Category: Zhang D]]
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[[Category: Zhang K]]

Current revision

Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab

PDB ID 8d0a

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OCA

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