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8doc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RPE65 in complex with compound 16e and palmitate== | |
| + | <StructureSection load='8doc' size='340' side='right'caption='[[8doc]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8doc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DOC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SYL:(1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol'>SYL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8doc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8doc OCA], [https://pdbe.org/8doc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8doc RCSB], [https://www.ebi.ac.uk/pdbsum/8doc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8doc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Retinoid isomerohydrolase|Retinoid isomerohydrolase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Bassetto | + | __TOC__ |
| - | [[Category: Kiser | + | </StructureSection> |
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bassetto M]] | ||
| + | [[Category: Kiser PD]] | ||
Current revision
Crystal structure of RPE65 in complex with compound 16e and palmitate
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