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8e6e
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8e6e is ON HOLD Authors: Liu, L., Lovell, S., Battaile, K.P., Madden, T.K., Groutas, W.C. Description: Crystal structure of MERS 3CL protease in co...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of MERS 3CL protease in complex with a phenyl sulfane inhibitor== | |
| - | + | <StructureSection load='8e6e' size='340' side='right'caption='[[8e6e]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E6E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UUR:2-phenylsulfanylethyl+~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate'>UUR</scene>, <scene name='pdbligand=UV2:(1R,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-[(N-{[2-(phenylsulfanyl)ethoxy]carbonyl}-L-leucyl)amino]propane-1-sulfonic+acid'>UV2</scene></td></tr> |
| - | [[Category: Battaile | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e6e OCA], [https://pdbe.org/8e6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e6e RCSB], [https://www.ebi.ac.uk/pdbsum/8e6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e6e ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/A0A1L2E0X0_MERS A0A1L2E0X0_MERS] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
| + | [[Category: Battaile KP]] | ||
| + | [[Category: Groutas WC]] | ||
| + | [[Category: Liu L]] | ||
| + | [[Category: Lovell S]] | ||
| + | [[Category: Madden TK]] | ||
Current revision
Crystal structure of MERS 3CL protease in complex with a phenyl sulfane inhibitor
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