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1nuh

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[[Image:1nuh.gif|left|200px]]
[[Image:1nuh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1nuh |SIZE=350|CAPTION= <scene name='initialview01'>1nuh</scene>, resolution 2.51&Aring;
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The line below this paragraph, containing "STRUCTURE_1nuh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PA5:5-PHOSPHOARABINONIC+ACID'>PA5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase Glucose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 5.3.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= GPI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1nuh| PDB=1nuh | SCENE= }}
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|RELATEDENTRY=[[1iat|1IAT]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nuh OCA], [http://www.ebi.ac.uk/pdbsum/1nuh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nuh RCSB]</span>
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}}
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'''The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate'''
'''The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Davies, C.]]
[[Category: Davies, C.]]
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[[Category: aldose-ketose isomerase]]
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[[Category: Aldose-ketose isomerase]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycolysis enzyme]]
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[[Category: Glycolysis enzyme]]
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[[Category: neurotrophic growth factor]]
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[[Category: Neurotrophic growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:59:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:40 2008''
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Revision as of 23:59, 2 May 2008

Image:1nuh.gif

Template:STRUCTURE 1nuh

The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate


Contents

Overview

Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate. Outside the cell, however, the protein appears to function as a cytokine. A crystal structure of human PGI bound with 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate) intermediate of the reaction, has been determined at 2.5 A resolution. The structure helps to confirm the assignment of Glu357 as the base catalyst in the isomerase reaction.

Disease

Known disease associated with this structure: Hemolytic anemia due to glucosephosphate isomerase deficiency OMIM:[172400], Hydrops fetalis, one form OMIM:[172400]

About this Structure

1NUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human phosphoglucose isomerase complexed with a transition-state analogue., Davies C, Muirhead H, Chirgwin J, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1111-3. Epub 2003, May 23. PMID:12777791 Page seeded by OCA on Sat May 3 02:59:40 2008

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