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8esi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8esi is ON HOLD Authors: Walker, M.E., Lim, L., Redinbo, M.R. Description: Bile Salt Hydrolase from B. longum with covalent inhibitor bound [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Bile Salt Hydrolase from B. longum with covalent inhibitor bound== | |
| - | + | <StructureSection load='8esi' size='340' side='right'caption='[[8esi]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8esi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WSR:(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl+hydrogen+sulfate+(non-preferred+name)'>WSR</scene></td></tr> |
| - | [[Category: Lim | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esi OCA], [https://pdbe.org/8esi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esi RCSB], [https://www.ebi.ac.uk/pdbsum/8esi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esi ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bifidobacterium longum]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lim L]] | ||
| + | [[Category: Redinbo MR]] | ||
| + | [[Category: Walker ME]] | ||
Current revision
Bile Salt Hydrolase from B. longum with covalent inhibitor bound
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