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2z1g

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Current revision (13:18, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2z1g' size='340' side='right'caption='[[2z1g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2z1g' size='340' side='right'caption='[[2z1g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z1G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z1G FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z1h|2z1h]], [[2z1i|2z1i]], [[2z1j|2z1j]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1g OCA], [https://pdbe.org/2z1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z1g RCSB], [https://www.ebi.ac.uk/pdbsum/2z1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1g OCA], [https://pdbe.org/2z1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z1g RCSB], [https://www.ebi.ac.uk/pdbsum/2z1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI]] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]
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[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ribonuclease H]]
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[[Category: Fukuchi S]]
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[[Category: Fukuchi, S]]
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[[Category: Kanaya S]]
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[[Category: Kanaya, S]]
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[[Category: Koga Y]]
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[[Category: Koga, Y]]
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[[Category: Nishikawa K]]
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[[Category: Nishikawa, K]]
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[[Category: Takano K]]
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[[Category: Takano, K]]
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[[Category: You DJ]]
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[[Category: You, D J]]
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[[Category: Hydrolase]]
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[[Category: Rnase hi]]
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[[Category: Surface-charge residue]]
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[[Category: Thermostability]]
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Current revision

Crystal structure of E.coli RNase HI surface charged mutant(Q4R/T40E/Q72H/Q76K/Q80E/T92K/Q105K)

PDB ID 2z1g

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