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2z2l

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==Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae==
==Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae==
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<StructureSection load='2z2l' size='340' side='right' caption='[[2z2l]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='2z2l' size='340' side='right'caption='[[2z2l]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z2l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z2L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z2l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z2L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z2m|2z2m]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pbpX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z2l OCA], [https://pdbe.org/2z2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z2l RCSB], [https://www.ebi.ac.uk/pdbsum/2z2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z2l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z2l OCA], [http://pdbe.org/2z2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z2l RCSB], [http://www.ebi.ac.uk/pdbsum/2z2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z2l ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PBPX_STRR6 PBPX_STRR6]] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
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[https://www.uniprot.org/uniprot/PBPX_STRPN PBPX_STRPN] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/2z2l_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/2z2l_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2z2l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2z2l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Takeuchi, Y]]
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[[Category: Large Structures]]
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[[Category: Watanabe, T]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Yamada, M]]
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[[Category: Takeuchi Y]]
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[[Category: Antibiotic]]
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[[Category: Watanabe T]]
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[[Category: Biosynthetic protein]]
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[[Category: Yamada M]]
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[[Category: Cell wall]]
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[[Category: Penicillin-binding]]
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[[Category: Peptidoglycan synthesis]]
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Current revision

Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae

PDB ID 2z2l

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