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2z71
From Proteopedia
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==Structure of truncated mutant CYS1GLY of penicillin V acylase from bacillus sphaericus co-crystallized with penicillin V== | ==Structure of truncated mutant CYS1GLY of penicillin V acylase from bacillus sphaericus co-crystallized with penicillin V== | ||
| - | <StructureSection load='2z71' size='340' side='right' caption='[[2z71]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='2z71' size='340' side='right'caption='[[2z71]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2z71]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2z71]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z71 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNV:(2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-(2-PHENOXYACETAMIDO)-4-THIA-1-+AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC+ACID'>PNV</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z71 OCA], [https://pdbe.org/2z71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z71 RCSB], [https://www.ebi.ac.uk/pdbsum/2z71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z71 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Lysinibacillus sphaericus]] |
| - | [[Category: Brannigan | + | [[Category: Brannigan J]] |
| - | [[Category: Dodson | + | [[Category: Dodson GG]] |
| - | [[Category: Pathak | + | [[Category: Pathak MC]] |
| - | [[Category: Suresh | + | [[Category: Suresh CG]] |
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Current revision
Structure of truncated mutant CYS1GLY of penicillin V acylase from bacillus sphaericus co-crystallized with penicillin V
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