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2z95

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==Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5==
==Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5==
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<StructureSection load='2z95' size='340' side='right' caption='[[2z95]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='2z95' size='340' side='right'caption='[[2z95]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z95]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z95 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z95]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z95 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rfbD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase GDP-mannose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.47 4.2.1.47] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z95 OCA], [https://pdbe.org/2z95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z95 RCSB], [https://www.ebi.ac.uk/pdbsum/2z95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z95 ProSAT], [https://www.topsan.org/Proteins/RSGI/2z95 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z95 OCA], [http://pdbe.org/2z95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z95 RCSB], [http://www.ebi.ac.uk/pdbsum/2z95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z95 ProSAT], [http://www.topsan.org/Proteins/RSGI/2z95 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/O67175_AQUAE O67175_AQUAE]] Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (By similarity).[HAMAP-Rule:MF_00955]
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[https://www.uniprot.org/uniprot/O67175_AQUAE O67175_AQUAE] Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (By similarity).[HAMAP-Rule:MF_00955]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aquae]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: GDP-mannose 4,6-dehydratase]]
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[[Category: Large Structures]]
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[[Category: Kuramitsu, S]]
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[[Category: Kuramitsu S]]
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[[Category: Niwa, H]]
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[[Category: Niwa H]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Lyase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Short-chain dehydrogenase/reductase]]
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Current revision

Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5

PDB ID 2z95

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