2za2

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{{Seed}}
 
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[[Image:2za2.png|left|200px]]
 
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==Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum==
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The line below this paragraph, containing "STRUCTURE_2za2", creates the "Structure Box" on the page.
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<StructureSection load='2za2' size='340' side='right'caption='[[2za2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2za2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZA2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2za2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2za2 OCA], [https://pdbe.org/2za2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2za2 RCSB], [https://www.ebi.ac.uk/pdbsum/2za2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2za2 ProSAT]</span></td></tr>
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{{STRUCTURE_2za2| PDB=2za2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8T6J6_PLAFA Q8T6J6_PLAFA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/2za2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2za2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we report the X-ray analysis of apo, substrate or product-complex forms of OMPDC from Plasmodium falciparum (PfOMPDC) at 2.7, 2.65 and 2.65 A, respectively. The structural analysis provides the substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site. The structural basis of substrate or product binding to PfOMPDC will help to uncover the decarboxylation mechanism and facilitate structure-based optimization of antimalarial drugs.
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===Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum===
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Structural basis for the decarboxylation of orotidine 5'-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase.,Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:17981823<ref>PMID:17981823</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2za2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17981823 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17981823}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2ZA2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA2 OCA].
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==Reference==
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<ref group="xtra">PMID:17981823</ref><references group="xtra"/>
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Inoue, T.]]
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[[Category: Inoue T]]
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[[Category: Tokuoka, K.]]
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[[Category: Tokuoka K]]
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[[Category: Lyase]]
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[[Category: Orotidine 5'-monophosphate decarboxylase]]
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[[Category: Plasmodium falciparum]]
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[[Category: Pyrimidine biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:13:47 2009''
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Current revision

Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum

PDB ID 2za2

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