This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2zaw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:28, 1 November 2023) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2zaw.jpg|left|200px]]<br /><applet load="2zaw" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2zaw, resolution 1.55&Aring;" />
 
-
'''Crystal Structure of Ferric Cytochrome P450cam Reconstituted with 6-Methyl-6-depropionated Hemin'''<br />
 
-
==About this Structure==
+
==Crystal Structure of Ferric Cytochrome P450cam Reconstituted with 6-Methyl-6-depropionated Hemin==
-
2ZAW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=6HE:'>6HE</scene> and <scene name='pdbligand=CAM:'>CAM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Camphor_5-monooxygenase Camphor 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.1 1.14.15.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAW OCA].
+
<StructureSection load='2zaw' size='340' side='right'caption='[[2zaw]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2zaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZAW FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6HE:6-METHY-6-DEPROPIONATEHEMIN'>6HE</scene>, <scene name='pdbligand=CAM:CAMPHOR'>CAM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zaw OCA], [https://pdbe.org/2zaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zaw RCSB], [https://www.ebi.ac.uk/pdbsum/2zaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zaw ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CPXA_PSEPU CPXA_PSEPU] Involved in a camphor oxidation system.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/2zaw_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zaw ConSurf].
 +
<div style="clear:both"></div>
-
==Reference==
+
==See Also==
-
Evaluation of the functional role of the heme-6-propionate side chain in cytochrome P450cam., Harada K, Sakurai K, Ikemura K, Ogura T, Hirota S, Shimada H, Hayashi T, J Am Chem Soc. 2008 Jan 16;130(2):432-3. Epub 2007 Dec 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18088124 18088124]
+
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
-
[[Category: Camphor 5-monooxygenase]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
-
[[Category: Single protein]]
+
[[Category: Harada K]]
-
[[Category: Harada, K.]]
+
[[Category: Hayashi T]]
-
[[Category: Hayashi, T.]]
+
[[Category: Sakurai K]]
-
[[Category: Sakurai, K.]]
+
[[Category: Shimada H]]
-
[[Category: Shimada, H.]]
+
[[Category: Tsukihara T]]
-
[[Category: Tsukihara, T.]]
+
-
[[Category: 6HE]]
+
-
[[Category: CAM]]
+
-
[[Category: CL]]
+
-
[[Category: K]]
+
-
[[Category: camphor-hydroxylase]]
+
-
[[Category: heme]]
+
-
[[Category: iron]]
+
-
[[Category: membrane]]
+
-
[[Category: metal-binding]]
+
-
[[Category: monooxygenase]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: p450cam]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:13 2008''
+

Current revision

Crystal Structure of Ferric Cytochrome P450cam Reconstituted with 6-Methyl-6-depropionated Hemin

PDB ID 2zaw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools