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2zc7

From Proteopedia

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{{Seed}}
 
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[[Image:2zc7.jpg|left|200px]]
 
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==Crystal Structure of Class C beta-Lactamase ACT-1==
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The line below this paragraph, containing "STRUCTURE_2zc7", creates the "Structure Box" on the page.
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<StructureSection load='2zc7' size='340' side='right'caption='[[2zc7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zc7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZC7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zc7 OCA], [https://pdbe.org/2zc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zc7 RCSB], [https://www.ebi.ac.uk/pdbsum/2zc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zc7 ProSAT]</span></td></tr>
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{{STRUCTURE_2zc7| PDB=2zc7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q48428_KLEPN Q48428_KLEPN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zc7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zc7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystallographic structure of ACT-1, which is the first plasmid-mediated AmpC-type beta-lactamase to have been completely analyzed in terms of nucleotide sequence and which has a high degree of sequence similarity to the chromosomal AmpC enzymes of Enterobacter cloacae and the plasmid-encoded MIR-1, has been solved at 2.4 A resolution. The overall structure of ACT-1 is similar to those of other class C beta-lactamases, such as the AmpC enzymes from E. cloacae P99 and Escherichia coli.
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===Crystal Structure of Class C beta-Lactamase ACT-1===
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Structure of the plasmid-mediated class C beta-lactamase ACT-1.,Shimizu-Ibuka A, Bauvois C, Sakai H, Galleni M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):334-7. Epub 2008 Apr 5. PMID:18453698<ref>PMID:18453698</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zc7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18453698}}, adds the Publication Abstract to the page
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18453698 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18453698}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2ZC7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC7 OCA].
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==Reference==
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Structure of the plasmid-mediated class C beta-lactamase ACT-1., Shimizu-Ibuka A, Bauvois C, Sakai H, Galleni M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):334-7. Epub 2008 Apr 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453698 18453698]
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Galleni, M.]]
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[[Category: Galleni M]]
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[[Category: Sakai, H.]]
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[[Category: Sakai H]]
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[[Category: Shimizu-Ibuka, A.]]
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[[Category: Shimizu-Ibuka A]]
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[[Category: Hydrolase]]
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[[Category: Two-domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:36:08 2008''
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Current revision

Crystal Structure of Class C beta-Lactamase ACT-1

PDB ID 2zc7

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