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2zg3

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==Crystal Structure of Two N-terminal Domains of Native Siglec-5 in Complex with 3'-Sialyllactose==
==Crystal Structure of Two N-terminal Domains of Native Siglec-5 in Complex with 3'-Sialyllactose==
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<StructureSection load='2zg3' size='340' side='right' caption='[[2zg3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='2zg3' size='340' side='right'caption='[[2zg3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zg3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZG3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZG3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o7s|1o7s]], [[1qfo|1qfo]], [[2zg1|2zg1]], [[2zg2|2zg2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIGLEC5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zg3 OCA], [https://pdbe.org/2zg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zg3 RCSB], [https://www.ebi.ac.uk/pdbsum/2zg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zg3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zg3 OCA], [http://pdbe.org/2zg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zg3 RCSB], [http://www.ebi.ac.uk/pdbsum/2zg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zg3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SIGL5_HUMAN SIGL5_HUMAN]] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
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[https://www.uniprot.org/uniprot/SIGL5_HUMAN SIGL5_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Sun, P D]]
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[[Category: Large Structures]]
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[[Category: Zhuravleva, M A]]
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[[Category: Sun PD]]
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[[Category: 3'-sialyllactose complex]]
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[[Category: Zhuravleva MA]]
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[[Category: C2-set]]
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[[Category: Cell adhesion]]
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[[Category: Glycoprotein]]
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[[Category: Ig-like domain]]
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[[Category: Immune system-carbohydrate binding protein complex]]
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[[Category: Immunoglobulin domain]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Sialic acid]]
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[[Category: Siglec-5 inhibitory receptor]]
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[[Category: Transmembrane]]
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[[Category: Two-domain structure]]
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[[Category: V-set]]
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Current revision

Crystal Structure of Two N-terminal Domains of Native Siglec-5 in Complex with 3'-Sialyllactose

PDB ID 2zg3

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