This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2zir

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:36, 1 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2zir' size='340' side='right'caption='[[2zir]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2zir' size='340' side='right'caption='[[2zir]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2zir]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2zir]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIR FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH7:2-[(S)-(4-CHLOROPHENYL)(HYDROXY)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-N-MORPHOLIN-4-YL-7-PHENYL-1-BENZOFURAN-5-CARBOXAMIDE'>NH7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zis|2zis]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH7:2-[(S)-(4-CHLOROPHENYL)(HYDROXY)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-N-MORPHOLIN-4-YL-7-PHENYL-1-BENZOFURAN-5-CARBOXAMIDE'>NH7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fnta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zir OCA], [https://pdbe.org/2zir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zir RCSB], [https://www.ebi.ac.uk/pdbsum/2zir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zir ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zir OCA], [https://pdbe.org/2zir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zir RCSB], [https://www.ebi.ac.uk/pdbsum/2zir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zir ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[https://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
+
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 38: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Protein farnesyltransferase]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Fukami, T A]]
+
[[Category: Fukami TA]]
-
[[Category: Ishii, N]]
+
[[Category: Ishii N]]
-
[[Category: Kondoh, O]]
+
[[Category: Kondoh O]]
-
[[Category: Nagata, Y]]
+
[[Category: Nagata Y]]
-
[[Category: Sogabe, S]]
+
[[Category: Sogabe S]]
-
[[Category: Metal-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Prenyltransferase]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP

PDB ID 2zir

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zir"
Personal tools