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2zpy

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==Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide==
==Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide==
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<StructureSection load='2zpy' size='340' side='right' caption='[[2zpy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2zpy' size='340' side='right'caption='[[2zpy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zpy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZPY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZPY FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gc7|1gc7]], [[1j19|1j19]], [[2yvc|2yvc]], [[2ems|2ems]], [[2emt|2emt]], [[2d2q|2d2q]], [[1gc6|1gc6]], [[2d10|2d10]], [[2d11|2d11]], [[1isn|1isn]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rdx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zpy OCA], [https://pdbe.org/2zpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zpy RCSB], [https://www.ebi.ac.uk/pdbsum/2zpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zpy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zpy OCA], [http://pdbe.org/2zpy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zpy RCSB], [http://www.ebi.ac.uk/pdbsum/2zpy PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
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[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/2zpy_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/2zpy_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2zpy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zpy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Radixin|Radixin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Fukami, Y]]
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[[Category: Mus musculus]]
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[[Category: Hakoshima, T]]
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[[Category: Fukami Y]]
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[[Category: Kitano, K]]
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[[Category: Hakoshima T]]
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[[Category: Maesaki, R]]
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[[Category: Kitano K]]
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[[Category: Mori, T]]
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[[Category: Maesaki R]]
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[[Category: Terawaki, S]]
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[[Category: Mori T]]
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[[Category: Actin capping]]
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[[Category: Terawaki S]]
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[[Category: Actin-binding]]
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[[Category: Cd44]]
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[[Category: Cell adhesion]]
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[[Category: Cell membrane]]
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[[Category: Cytoskeleton]]
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[[Category: Ferm domain]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Proteoglycan]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Receptor]]
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[[Category: Structural protein]]
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[[Category: Sulfation]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide

PDB ID 2zpy

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