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2zqc
From Proteopedia
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| - | [[Image:2zqc.png|left|200px]] | ||
| - | + | ==Aztreonam acyl-intermediate structure of class a beta-lactam Toho-1 E166A/R274N/R276N triple mutant== | |
| - | + | <StructureSection load='2zqc' size='340' side='right'caption='[[2zqc]], [[Resolution|resolution]] 1.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2zqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZR:2-({[(1Z)-1-(2-AMINO-1,3-THIAZOL-4-YL)-2-OXO-2-{[(2S,3S)-1-OXO-3-(SULFOAMINO)BUTAN-2-YL]AMINO}ETHYLIDENE]AMINO}OXY)-2-METHYLPROPANOIC+ACID'>AZR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[2zqc]] is a 1 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqc OCA], [https://pdbe.org/2zqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqc RCSB], [https://www.ebi.ac.uk/pdbsum/2zqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqc ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqc_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqc ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Beta-lactamase|Beta-lactamase]] | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Ishii | + | [[Category: Large Structures]] |
| - | [[Category: Matsuzawa | + | [[Category: Ishii Y]] |
| - | [[Category: Miyano | + | [[Category: Matsuzawa H]] |
| - | [[Category: Nitanai | + | [[Category: Miyano M]] |
| - | [[Category: Shimamura | + | [[Category: Nitanai Y]] |
| - | [[Category: Takehira | + | [[Category: Shimamura T]] |
| - | [[Category: Uchiyama | + | [[Category: Takehira M]] |
| - | [[Category: Yutani | + | [[Category: Uchiyama T]] |
| - | + | [[Category: Yutani K]] | |
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Current revision
Aztreonam acyl-intermediate structure of class a beta-lactam Toho-1 E166A/R274N/R276N triple mutant
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Categories: Escherichia coli | Large Structures | Ishii Y | Matsuzawa H | Miyano M | Nitanai Y | Shimamura T | Takehira M | Uchiyama T | Yutani K
