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2zr5

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(New page: '''Unreleased structure''' The entry 2zr5 is ON HOLD until Paper Publication Authors: Jobichen, C., Yih-Cherng, L., Sivaraman, J. Description: Crystal structure of a mutant PIN1 peptid...)
Current revision (13:50, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2zr5 is ON HOLD until Paper Publication
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==Crystal structure of a mutant PIN1 peptidyl-prolyl cis-trans isomerase==
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<StructureSection load='2zr5' size='340' side='right'caption='[[2zr5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZR5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr5 OCA], [https://pdbe.org/2zr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zr5 RCSB], [https://www.ebi.ac.uk/pdbsum/2zr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zr5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zr5 ConSurf].
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<div style="clear:both"></div>
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Authors: Jobichen, C., Yih-Cherng, L., Sivaraman, J.
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==See Also==
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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Description: Crystal structure of a mutant PIN1 peptidyl-prolyl cis-trans isomerase
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 12:29:39 2008''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jobichen C]]
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[[Category: Sivaraman J]]
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[[Category: Yih-Cherng L]]

Current revision

Crystal structure of a mutant PIN1 peptidyl-prolyl cis-trans isomerase

PDB ID 2zr5

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