This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2zth

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:54, 1 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of holo form of rat catechol-o-methyltransferase==
==Crystal structure of holo form of rat catechol-o-methyltransferase==
-
<StructureSection load='2zth' size='340' side='right' caption='[[2zth]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='2zth' size='340' side='right'caption='[[2zth]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2zth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZTH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2zth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vid|1vid]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">liver ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zth OCA], [https://pdbe.org/2zth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zth RCSB], [https://www.ebi.ac.uk/pdbsum/2zth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zth ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zth OCA], [http://pdbe.org/2zth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zth RCSB], [http://www.ebi.ac.uk/pdbsum/2zth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zth ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 31:
==See Also==
==See Also==
-
*[[Catechol O-methyltransferase|Catechol O-methyltransferase]]
+
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
+
[[Category: Large Structures]]
-
[[Category: Catechol O-methyltransferase]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Tsuji, E]]
+
[[Category: Tsuji E]]
-
[[Category: Alternative initiation]]
+
-
[[Category: Catecholamine metabolism]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Membrane]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Methyltransferase]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: S-adenosyl-l-methionine]]
+
-
[[Category: S-adenosylmethionine dependent methyltransferase]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal structure of holo form of rat catechol-o-methyltransferase

PDB ID 2zth

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zth"
Personal tools