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2zv6

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[[Image:2zv6.png|left|200px]]
 
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{{STRUCTURE_2zv6| PDB=2zv6 | SCENE= }}
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==Crystal structure of human squamous cell carcinoma antigen 1==
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<StructureSection load='2zv6' size='340' side='right'caption='[[2zv6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zv6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZV6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv6 OCA], [https://pdbe.org/2zv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zv6 RCSB], [https://www.ebi.ac.uk/pdbsum/2zv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN] May act as a protease inhibitor to modulate the host immune response against tumor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zv6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zv6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Squamous cell carcinoma antigen 1 (SCCA1), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that SCCA1 acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). The present study determined the crystal structure of SCCA1, suggesting that the reactive center loop (RCL) of SCCA1, a recognition site of proteinase, is very flexible and located away form the main-body of SCCA1. We show that the inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, we found that a mutant protein created by replacing one amino acid in RCL maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased.
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===Crystal structure of human squamous cell carcinoma antigen 1===
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Crystal structure of SCCA1 and insight about the interaction with JNK1.,Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M Biochem Biophys Res Commun. 2009 Feb 27;380(1):143-7. Epub 2009 Jan 21. PMID:19166818<ref>PMID:19166818</ref>
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{{ABSTRACT_PUBMED_19166818}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2zv6" style="background-color:#fffaf0;"></div>
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[[2zv6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV6 OCA].
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==See Also==
==See Also==
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*[[Serpin|Serpin]]
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*[[Serpin 3D structures|Serpin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019166818</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hibino, T.]]
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[[Category: Large Structures]]
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[[Category: Katagiri, C.]]
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[[Category: Hibino T]]
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[[Category: Matoba, Y.]]
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[[Category: Katagiri C]]
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[[Category: Sugiyama, M.]]
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[[Category: Matoba Y]]
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[[Category: Zheng, B.]]
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[[Category: Sugiyama M]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Zheng B]]
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[[Category: Protease inhibitor]]
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[[Category: Reactive site loop]]
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[[Category: Serine protease inhibitor]]
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[[Category: Serine proteinase inhibitor]]
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Current revision

Crystal structure of human squamous cell carcinoma antigen 1

PDB ID 2zv6

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