2zza

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[[Image:2zza.png|left|200px]]
 
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{{STRUCTURE_2zza| PDB=2zza | SCENE= }}
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==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==
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<StructureSection load='2zza' size='340' side='right'caption='[[2zza]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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[[2zza]] is a 2 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [https://pdbe.org/2zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [https://www.ebi.ac.uk/pdbsum/2zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zza_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zza ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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[[Category: Dihydrofolate reductase]]
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__TOC__
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[[Category: Moritella profunda]]
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</StructureSection>
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[[Category: Akasaka, K.]]
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[[Category: Large Structures]]
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[[Category: Gekko, K.]]
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[[Category: Hata, K.]]
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[[Category: Murakami, C.]]
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[[Category: Ohmae, E.]]
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[[Category: Shiro, Y.]]
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[[Category: Tanaka, T.]]
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[[Category: Deep-sea]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Folic acid]]
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[[Category: High pressure]]
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[[Category: Low temperature]]
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[[Category: Moritella profunda]]
[[Category: Moritella profunda]]
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[[Category: Nadp]]
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[[Category: Akasaka K]]
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[[Category: Oxidoreductase]]
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[[Category: Gekko K]]
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[[Category: Piezophilic]]
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[[Category: Hata K]]
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[[Category: Psychrophilic]]
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[[Category: Murakami C]]
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[[Category: Psychropiezophilic]]
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[[Category: Ohmae E]]
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[[Category: Shiro Y]]
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[[Category: Tanaka T]]

Current revision

Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate

PDB ID 2zza

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OCA

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