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3a1h

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[[Image:3a1h.png|left|200px]]
 
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==Crystal Structure Analysis of the Collagen-like Peptide, (PPG)4-OTG-(PPG)4==
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The line below this paragraph, containing "STRUCTURE_3a1h", creates the "Structure Box" on the page.
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<StructureSection load='3a1h' size='340' side='right'caption='[[3a1h]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a1h]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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{{STRUCTURE_3a1h| PDB=3a1h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1h OCA], [https://pdbe.org/3a1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1h RCSB], [https://www.ebi.ac.uk/pdbsum/3a1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1h ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The single-crystal structures of three collagen-like host-guest peptides, (Pro-Pro-Gly)(4) -Hyp-Yaa-Gly-(Pro-Pro-Gly)(4) [Yaa = Thr, Val, Ser; Hyp = (4R)-4-hydroxyproline] were analyzed at atomic resolution. These peptides adopted a 7/2-helical structure similar to that of the (Pro-Pro-Gly)(9) peptide. The stability of these triple helices showed a similar tendency to that observed in Ac-(Gly-Hyp-Yaa)(10) -NH(2) (Yaa = Thr, Val, Ser) peptides. On the basis of their detailed structures, the differences in the triple-helical stabilities of the peptides containing a Hyp-Thr-Gly, Hyp-Val-Gly, or Hyp-Ser-Gly sequence were explained in terms of van der Waals interactions and dipole-dipole interaction between the Hyp residue in the X position and the Yaa residue in the Y position involved in the Hyp(X):Yaa(Y) stacking pair. This idea also explains the inability of Ac-(Gly-Hyp-alloThr)(10) -NH(2) and Ac-(Gly-Hyp-Ala)(10) -NH(2) peptides to form triple helices. In the Hyp(X):Thr(Y), Hyp(X):Val(Y), and Hyp(X):Ser(Y) stacking pairs, the proline ring of the Hyp residues adopts an up-puckering conformation, in agreement with the residual preference of Hyp, but in disagreement with the positional preference of X in the Gly-Xaa-Yaa sequence. (c) 2011 Wiley Periodicals, Inc. Biopolymers 95: 628-640, 2011.
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===Crystal Structure Analysis of the Collagen-like Peptide, (PPG)4-OTG-(PPG)4===
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Stabilization of triple-helical structures of collagen peptides containing a Hyp-Thr-Gly, Hyp-Val-Gly, or Hyp-Ser-Gly sequence.,Okuyama K, Miyama K, Morimoto T, Masakiyo K, Mizuno K, Bachinger HP Biopolymers. 2011 Sep;95(9):628-40. doi: 10.1002/bip.21625. Epub 2011 Mar, 25. PMID:21442606<ref>PMID:21442606</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21442606}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3a1h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21442606 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21442606}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3a1h]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1H OCA].
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[[Category: Bachinger HP]]
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[[Category: Miyama K]]
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==Reference==
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[[Category: Mizuno K]]
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<ref group="xtra">PMID:021442606</ref><references group="xtra"/>
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[[Category: Okuyama K]]
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[[Category: Bachinger, H P.]]
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[[Category: Miyama, K.]]
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[[Category: Mizuno, K.]]
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[[Category: Okuyama, K.]]
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[[Category: Collagen helix]]
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[[Category: Host-guest peptide]]
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[[Category: Structural protein]]
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[[Category: Twinned crystal]]
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Current revision

Crystal Structure Analysis of the Collagen-like Peptide, (PPG)4-OTG-(PPG)4

PDB ID 3a1h

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