This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ayw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:38, 1 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of Human Nucleosome Core Particle Containing H3K56Q mutation==
==Crystal Structure of Human Nucleosome Core Particle Containing H3K56Q mutation==
-
<StructureSection load='3ayw' size='340' side='right' caption='[[3ayw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+
<StructureSection load='3ayw' size='340' side='right'caption='[[3ayw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ayw]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AYW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ayw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AYW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3afa|3afa]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ayw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ayw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ayw RCSB], [http://www.ebi.ac.uk/pdbsum/3ayw PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ayw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ayw OCA], [https://pdbe.org/3ayw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ayw RCSB], [https://www.ebi.ac.uk/pdbsum/3ayw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ayw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
+
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3ayw" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Histone|Histone]]
+
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 25: Line 27:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Iwasaki, W]]
+
[[Category: Large Structures]]
-
[[Category: Kagawa, W]]
+
[[Category: Iwasaki W]]
-
[[Category: Kawaguchi, K]]
+
[[Category: Kagawa W]]
-
[[Category: Kurumizaka, H]]
+
[[Category: Kawaguchi K]]
-
[[Category: Shibata, T]]
+
[[Category: Kurumizaka H]]
-
[[Category: Tachiwana, H]]
+
[[Category: Shibata T]]
-
[[Category: Histone-fold]]
+
[[Category: Tachiwana H]]
-
[[Category: Nucleosome]]
+
-
[[Category: Structural protein-dna complex]]
+

Current revision

Crystal Structure of Human Nucleosome Core Particle Containing H3K56Q mutation

PDB ID 3ayw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ayw"
Personal tools