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3azh

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==Crystal Structure of Human Nucleosome Core Particle Containing H3K122Q mutation==
==Crystal Structure of Human Nucleosome Core Particle Containing H3K122Q mutation==
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<StructureSection load='3azh' size='340' side='right' caption='[[3azh]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
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<StructureSection load='3azh' size='340' side='right'caption='[[3azh]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3azh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AZH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3azh]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3afa|3afa]], [[3ayw|3ayw]], [[3aze|3aze]], [[3azf|3azf]], [[3azg|3azg]], [[3azi|3azi]], [[3azj|3azj]], [[3azk|3azk]], [[3azl|3azl]], [[3azm|3azm]], [[3azn|3azn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azh RCSB], [http://www.ebi.ac.uk/pdbsum/3azh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3azh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azh OCA], [https://pdbe.org/3azh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3azh RCSB], [https://www.ebi.ac.uk/pdbsum/3azh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3azh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
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[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3azh" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Histone|Histone]]
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Iwasaki, W]]
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[[Category: Large Structures]]
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[[Category: Kagawa, W]]
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[[Category: Iwasaki W]]
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[[Category: Kawaguchi, K]]
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[[Category: Kagawa W]]
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[[Category: Kurumizaka, H]]
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[[Category: Kawaguchi K]]
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[[Category: Shibata, T]]
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[[Category: Kurumizaka H]]
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[[Category: Tachiwana, H]]
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[[Category: Shibata T]]
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[[Category: Histone-fold]]
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[[Category: Tachiwana H]]
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[[Category: Nucleosome]]
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[[Category: Structural protein-dna complex]]
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Current revision

Crystal Structure of Human Nucleosome Core Particle Containing H3K122Q mutation

PDB ID 3azh

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