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3b3x

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[[Image:3b3x.jpg|left|200px]]
 
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==Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate==
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The line below this paragraph, containing "STRUCTURE_3b3x", creates the "Structure Box" on the page.
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<StructureSection load='3b3x' size='340' side='right'caption='[[3b3x]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b3x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_licheniformis Bacillus licheniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B3X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A33:2-(CARBOXYMETHYL)-D-ASPARTIC+ACID'>A33</scene></td></tr>
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{{STRUCTURE_3b3x| PDB=3b3x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b3x OCA], [https://pdbe.org/3b3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b3x RCSB], [https://www.ebi.ac.uk/pdbsum/3b3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b3x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAC_BACLI BLAC_BACLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/3b3x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b3x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl aminocitrate 3 and the free tris-acid 4 have been tested against a member beta-lactamase from all distinct subgroups. They are novel inhibitors of class A beta-lactamases, still modest but more potent than citrate and isocitrate.
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'''Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate'''
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2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis.,Beck J, Sauvage E, Charlier P, Marchand-Brynaert J Bioorg Med Chem Lett. 2008 Jul 1;18(13):3764-8. Epub 2008 May 16. PMID:18515103<ref>PMID:18515103</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3b3x" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3B3X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_licheniformis Bacillus licheniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B3X OCA].
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus licheniformis]]
[[Category: Bacillus licheniformis]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Charlier P]]
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[[Category: Charlier, P.]]
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[[Category: Herman R]]
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[[Category: Herman, R.]]
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[[Category: Kerff F]]
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[[Category: Kerff, F.]]
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[[Category: Sauvage E]]
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[[Category: Sauvage, E.]]
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[[Category: Aminocitrate]]
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[[Category: Antibiotic resistance]]
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[[Category: Beta-lactamase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:22:10 2008''
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Current revision

Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate

PDB ID 3b3x

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