3bew

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:45, 1 November 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3bew.jpg|left|200px]]<br /><applet load="3bew" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="3bew, resolution 2.600&Aring;" />
 
-
'''10mer Crystal Structure of chicken MHC class I haplotype B21'''<br />
 
-
==Overview==
+
==10mer Crystal Structure of chicken MHC class I haplotype B21==
-
Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2( *)2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease.
+
<StructureSection load='3bew' size='340' side='right'caption='[[3bew]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3bew]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEW FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bew OCA], [https://pdbe.org/3bew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bew RCSB], [https://www.ebi.ac.uk/pdbsum/3bew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bew ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q95601_CHICK Q95601_CHICK]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bew_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bew ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2*2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease.
-
==About this Structure==
+
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.,Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J Immunity. 2007 Dec;27(6):885-99. PMID:18083574<ref>PMID:18083574</ref>
-
3BEW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEW OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding., Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J, Immunity. 2007 Dec;27(6):885-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18083574 18083574]
+
</div>
-
[[Category: Gallus gallus]]
+
<div class="pdbe-citations 3bew" style="background-color:#fffaf0;"></div>
-
[[Category: Protein complex]]
+
-
[[Category: Avila, D.]]
+
-
[[Category: Camp, S.]]
+
-
[[Category: Cerundolo, V.]]
+
-
[[Category: Collen, T.]]
+
-
[[Category: Dunbar, P R.]]
+
-
[[Category: Hateren, A van.]]
+
-
[[Category: Hunt, L.]]
+
-
[[Category: Jacob, J P.]]
+
-
[[Category: Johnston, F.]]
+
-
[[Category: Jones, E Y.]]
+
-
[[Category: Kaufman, J.]]
+
-
[[Category: Koch, M.]]
+
-
[[Category: Marston, D A.]]
+
-
[[Category: Salomonsen, J.]]
+
-
[[Category: Shaw, I.]]
+
-
[[Category: Wallny, H J.]]
+
-
[[Category: 10mer]]
+
-
[[Category: bulge]]
+
-
[[Category: chicken]]
+
-
[[Category: gtp-binding]]
+
-
[[Category: immune response]]
+
-
[[Category: immune system]]
+
-
[[Category: immunoglobulin domain]]
+
-
[[Category: mhc class i]]
+
-
[[Category: mhc i]]
+
-
[[Category: microtubule]]
+
-
[[Category: nucleotide-binding]]
+
-
[[Category: peptide]]
+
-
[[Category: polymorphism]]
+
-
[[Category: secreted]]
+
-
[[Category: water cushion]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:05:12 2008''
+
==See Also==
 +
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 +
*[[MHC 3D structures|MHC 3D structures]]
 +
*[[MHC I 3D structures|MHC I 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Gallus gallus]]
 +
[[Category: Large Structures]]
 +
[[Category: Avila D]]
 +
[[Category: Camp S]]
 +
[[Category: Cerundolo V]]
 +
[[Category: Collen T]]
 +
[[Category: Dunbar PR]]
 +
[[Category: Hunt L]]
 +
[[Category: Jacob JP]]
 +
[[Category: Johnston F]]
 +
[[Category: Jones EY]]
 +
[[Category: Kaufman J]]
 +
[[Category: Koch M]]
 +
[[Category: Marston DA]]
 +
[[Category: Salomonsen J]]
 +
[[Category: Shaw I]]
 +
[[Category: Wallny HJ]]
 +
[[Category: Van Hateren A]]

Current revision

10mer Crystal Structure of chicken MHC class I haplotype B21

PDB ID 3bew

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bew"
Personal tools