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3c1r

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{{Seed}}
 
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[[Image:3c1r.jpg|left|200px]]
 
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==Crystal structure of oxidized GRX1==
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The line below this paragraph, containing "STRUCTURE_3c1r", creates the "Structure Box" on the page.
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<StructureSection load='3c1r' size='340' side='right'caption='[[3c1r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C1R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_3c1r| PDB=3c1r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c1r OCA], [https://pdbe.org/3c1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c1r RCSB], [https://www.ebi.ac.uk/pdbsum/3c1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c1r ProSAT]</span></td></tr>
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</table>
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===Crystal structure of oxidized GRX1===
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== Function ==
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[https://www.uniprot.org/uniprot/GLRX1_YEAST GLRX1_YEAST] Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.<ref>PMID:9571241</ref> <ref>PMID:11875065</ref> <ref>PMID:12684511</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3C1R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1R OCA].
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Check<jmol>
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<jmolCheckbox>
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==Reference==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/3c1r_consurf.spt"</scriptWhenChecked>
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Glutathionylation-triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae., Yu J, Zhang NN, Yin PD, Cui PX, Zhou CZ, Proteins. 2008 Aug 15;72(3):1077-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18473363 18473363]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c1r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Yu, J.]]
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[[Category: Yu J]]
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[[Category: Zhou, C Z.]]
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[[Category: Zhou CZ]]
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[[Category: Cytoplasm]]
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[[Category: Electron transport]]
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[[Category: Oxidized form]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:02:19 2008''
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Current revision

Crystal structure of oxidized GRX1

PDB ID 3c1r

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