This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

3dlq

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Crystal structure of the IL-22/IL-22R1 complex

Structural highlights

3dlq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL22_HUMAN Cytokine that contributes to the inflammatory response in vivo.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.,Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I FEBS Lett. 2008 Sep 3;582(20):2985-92. Epub 2008 Aug 7. PMID:18675809^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. FEBS Lett. 2008 Sep 3;582(20):2985-92. Epub 2008 Aug 7. PMID:18675809 doi:10.1016/j.febslet.2008.07.046

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dlq"

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3dlq.png|left|200px]]
-<!--
+==Crystal structure of the IL-22/IL-22R1 complex==
-The line below this paragraph, containing "STRUCTURE_3dlq", creates the "Structure Box" on the page.
+<StructureSection load='3dlq' size='340' side='right'caption='[[3dlq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3dlq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DLQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlq OCA], [https://pdbe.org/3dlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dlq RCSB], [https://www.ebi.ac.uk/pdbsum/3dlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dlq ProSAT]</span></td></tr>
-{{STRUCTURE_3dlq|  PDB=3dlq  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dlq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dlq ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.
-===Crystal structure of the IL-22/IL-22R1 complex===
+Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.,Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I FEBS Lett. 2008 Sep 3;582(20):2985-92. Epub 2008 Aug 7. PMID:18675809<ref>PMID:18675809</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3dlq" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18675809}}, adds the Publication Abstract to the page
+*[[Interleukin 3D structures|Interleukin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18675809 is the PubMed ID number.
+*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_18675809}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-DLQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLQ OCA].
-==Reference==
-<ref group="xtra">PMID:18675809</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Bleicher, L.]]
+[[Category: Large Structures]]
-[[Category: Colau, D.]]
+[[Category: Bleicher L]]
-[[Category: Dumoutier, L.]]
+[[Category: Colau D]]
-[[Category: Moura, P R.de.]]
+[[Category: Dumoutier L]]
-[[Category: Polikarpov, I.]]
+[[Category: Polikarpov I]]
-[[Category: Renauld, J C.]]
+[[Category: Renauld J-C]]
-[[Category: Watanabe, L.]]
+[[Category: Watanabe L]]
-[[Category: Cytokine]]
+[[Category: De Moura PR]]
-[[Category: Cytokine-receptor complex]]
-[[Category: Cytokine/cytokine receptor complex]]
-[[Category: Fibronectin-iii]]
-[[Category: Glycoprotein]]
-[[Category: Membrane]]
-[[Category: Polymorphism]]
-[[Category: Receptor]]
-[[Category: Secreted]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:49:30 2009''

3dlq

From Proteopedia

Current revision

Crystal structure of the IL-22/IL-22R1 complex

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox