3drh

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{{Seed}}
 
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[[Image:3drh.jpg|left|200px]]
 
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==Crystal structure of Lactococcal OppA co-crystallized with Leu-enkephalin in an open conformation==
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The line below this paragraph, containing "STRUCTURE_3drh", creates the "Structure Box" on the page.
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<StructureSection load='3drh' size='340' side='right'caption='[[3drh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3drh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3drh OCA], [https://pdbe.org/3drh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3drh RCSB], [https://www.ebi.ac.uk/pdbsum/3drh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3drh ProSAT]</span></td></tr>
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{{STRUCTURE_3drh| PDB=3drh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A2RJ53_LACLM A2RJ53_LACLM]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3drh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3drh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Oligopeptide-binding protein A (OppA) from Lactococcus lactis binds peptides of an exceptionally wide range of lengths (4-35 residues), with no apparent sequence preference. Here, we present the crystal structures of OppA in the open- and closed-liganded conformations. The structures directly explain the protein's phenomenal promiscuity. A huge cavity allows binding of very long peptides, and a lack of constraints for the position of the N and C termini of the ligand is compatible with binding of peptides with varying lengths. Unexpectedly, the peptide's amino-acid composition (but not the exact sequence) appears to have a function in selection, with a preference for proline-rich peptides containing at least one isoleucine. These properties can be related to the physiology of the organism: L. lactis is auxotrophic for branched chain amino acids and favours proline-rich caseins as a source of amino acids. We propose a new mechanism for peptide selection based on amino-acid composition rather than sequence.
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===Crystal structure of Lactococcal OppA co-crystallized with Leu-enkephalin in an open conformation===
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The structural basis for peptide selection by the transport receptor OppA.,Berntsson RP, Doeven MK, Fusetti F, Duurkens RH, Sengupta D, Marrink SJ, Thunnissen AM, Poolman B, Slotboom DJ EMBO J. 2009 Mar 19. PMID:19300437<ref>PMID:19300437</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3drh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19300437}}, adds the Publication Abstract to the page
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19300437 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19300437}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Lactococcus lactis subsp. cremoris MG1363]]
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3DRH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRH OCA].
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[[Category: Large Structures]]
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[[Category: Berntsson RP-A]]
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==Reference==
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[[Category: Doeven MK]]
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<ref group="xtra">PMID:19300437</ref><references group="xtra"/>
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[[Category: Duurkens RH]]
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[[Category: Lactococcus lactis]]
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[[Category: Marrink S-J]]
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[[Category: Berntsson, R P.A.]]
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[[Category: Poolman B]]
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[[Category: Doeven, M K.]]
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[[Category: Sengupta D]]
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[[Category: Duurkens, R H.]]
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[[Category: Slotboom D-J]]
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[[Category: Marrink, S J.]]
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[[Category: Thunnissen A-M]]
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[[Category: Poolman, B.]]
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[[Category: Sengupta, D.]]
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[[Category: Slotboom, D J.]]
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[[Category: Thunnissen, A M.]]
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[[Category: Oligo-peptide binding]]
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[[Category: Peptide binding protein]]
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[[Category: Venus fly-trap]]
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[[Category: Voluminous binding cavity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:25:04 2009''
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Current revision

Crystal structure of Lactococcal OppA co-crystallized with Leu-enkephalin in an open conformation

PDB ID 3drh

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