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3ehr

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==Crystal Structure of Human Osteoclast Stimulating Factor==
==Crystal Structure of Human Osteoclast Stimulating Factor==
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<StructureSection load='3ehr' size='340' side='right' caption='[[3ehr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='3ehr' size='340' side='right'caption='[[3ehr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ehr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ehr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EHR FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ehq|3ehq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehr OCA], [https://pdbe.org/3ehr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ehr RCSB], [https://www.ebi.ac.uk/pdbsum/3ehr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehr OCA], [http://pdbe.org/3ehr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehr RCSB], [http://www.ebi.ac.uk/pdbsum/3ehr PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OSTF1_HUMAN OSTF1_HUMAN]] Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<ref>PMID:10092216</ref>
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[https://www.uniprot.org/uniprot/OSTF1_HUMAN OSTF1_HUMAN] Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<ref>PMID:10092216</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/3ehr_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/3ehr_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gao, Y]]
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[[Category: Large Structures]]
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[[Category: Niu, L]]
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[[Category: Gao Y]]
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[[Category: Teng, M]]
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[[Category: Niu L]]
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[[Category: Tong, S]]
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[[Category: Teng M]]
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[[Category: Zhang, X]]
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[[Category: Tong S]]
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[[Category: Zhou, H]]
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[[Category: Zhang X]]
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[[Category: Zhu, Z]]
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[[Category: Zhou H]]
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[[Category: Ank repeat]]
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[[Category: Zhu Z]]
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[[Category: Ankyrin repeat]]
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[[Category: Beta barrel]]
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[[Category: Helix-turn-helix]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Human Osteoclast Stimulating Factor

PDB ID 3ehr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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